Diagnostic chest x-rays and breast cancer risk before age 50 years for BRCA1 and BRCA2 mutation carriers

EM John; V McGuire; D Thomas; R Haile; H Ozcelik; RL Milne; A Felberg; DW West; A Miron; JA Knight; MB Terry; M Daly; SS Buys; IL Andrulis; JL Hopper; MC Southey; GG Giles; C Apicella; H Thorne; AS Whittemore

Journal article

Diagnostic chest x-rays and breast cancer risk before age 50 years for BRCA1 and BRCA2 mutation carriers

EM John, V McGuire, D Thomas, R Haile, H Ozcelik, RL Milne, A Felberg, DW West, A Miron, JA Knight, MB Terry, M Daly, SS Buys, IL Andrulis, JL Hopper, MC Southey, GG Giles, C Apicella, H Thorne, AS Whittemore

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2013

DOI: 10.1158/1055-9965.EPI-13-0189

Abstract

Background: The effects of low-dose medical radiation on breast cancer risk are uncertain, and few studies have included genetically susceptible women, such as those who carry germline BRCA1 and BRCA2 mutations. Methods: We studied 454 BRCA1 and 273 BRCA2 mutation carriers ages younger than 50 years from three breast cancer family registries in the United States, Canada, and Australia/New Zealand. We estimated breast cancer risk associated with diagnostic chest X-rays by comparing mutation carriers with breast cancer (cases) with those without breast cancer (controls). Exposure to chest X-rays was self-reported. Mammograms were not considered in the analysis. Results: After adjusting for kno..

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University of Melbourne Researchers

Roger Milne Author

Melissa Southey Author

Graham Giles Author

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Grants

Awarded by National Cancer Institute

Funding Acknowledgements

This study was supported by the National Cancer Institute grant RO1 CA097359 (to A. S. Whittemore). The Breast Cancer Family Registry (BCFR) is supported by National Cancer Institute grant UM1 CA164920 (to I. L. Andrulis, S. S. Buys, M. Daly, J.L. Hopper, E. M. John, M. B. Terry). The Australian site of the BCFR was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation, and the Victorian Breast Cancer Research Consortium. kConFab is supported by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia (to J.F. Sambrook). The Clinical Follow-UpStudy is funded by NHMRC grants 145684, 288704 and 454508 (to J.F. Sambrook).